Primary citation for GEMME:

• Laine, E.; Karami, Y.; Carbone, A. GEMME: A Simple and Fast Global Epistatic Model Predicting Mutational Effects. Mol. Biol. Evol. 2019, 36 (11), 2604–2619. doi:10.1093/molbev/msz179.

Work assessing different multilple sequence alignment generation protocols:

• Abakarova M; Marquet C; Rera M; Rost B; Laine E. Alignment-based Protein Mutational Landscape Prediction: Doing More with Less. Genome Biology and Evolution. 2023. doi:10.1093/gbe/evad201.

See how GEMME correlates with experimental thermodynamic stability in:

• Tsuboyama K; Dauparas J; Chen J; Laine E; Mohseni Behbahani Y; Weinstein JJ; Mangan NM; Ovchinnikov S; Rocklin GJ. Mega-scale experimental analysis of protein folding stability in biology and design. Nature. 2023. doi:10.1038/s41586-023-06328-6.