ProteoCast :

• Abakarova M, Freiberger MI, Liehrmann A, Rera M, Laine E. Proteome-wide Prediction of the Functional Impact of Missense Variants with ProteoCast. biorxiv; 2025 . doi.org/10.1101/2025.02.09.637326.

Primary citation for GEMME:

• Laine E; Karami Y; Carbone A. GEMME: A Simple and Fast Global Epistatic Model Predicting Mutational Effects. Mol. Biol. Evol. 2019, 36 (11), 2604–2619. doi:10.1093/molbev/msz179.

Work assessing different multilple sequence alignment generation protocols:

• Abakarova M; Marquet C; Rera M; Rost B; Laine E. Alignment-based Protein Mutational Landscape Prediction: Doing More with Less. Genome Biology and Evolution. 2023. doi:10.1093/gbe/evad201.

See how GEMME correlates with experimental thermodynamic stability in:

• Tsuboyama K; Dauparas J; Chen J; Laine E; Mohseni Behbahani Y; Weinstein JJ; Mangan NM; Ovchinnikov S; Rocklin GJ. Mega-scale experimental analysis of protein folding stability in biology and design. Nature. 2023. doi:10.1038/s41586-023-06328-6.